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Most data comes from Japanese cohorts. European and American guidelines (ACC/AHA/ESC) still endorse CHA₂DS₂-VASc. Until large-scale Western RCTs validate ABC2D, it remains a "supplementary" tool in the US/EU.
Recent studies and external validations indicate the score's diagnostic utility: Optimal Cutoff : A score of is typically used to predict ICAS-O. Sensitivity and Specificity abc2d score
Research published in the Journal of Neurosurgery identified 4 points as the optimal cutoff. A score of 4 or higher demonstrated approximately 92.2% sensitivity and 83.3% accuracy for identifying atherosclerotic occlusions. Most data comes from Japanese cohorts
The ABC2D score was designed to be: