If you are dead-set on using the actual Paint Tool SAI 2 software on your Mac, the only reliable way to do so is through emulation or compatibility layers. This allows you to run Windows software on macOS.
paint tool sai 2 mac download
As of 2025, there is no public beta, no announcement, and no roadmap for a native Mac version. Any website claiming “Paint Tool SAI 2 for Mac.dmg” is either a virus, a wrapper, or a scam. paint tool sai 2 mac download