Jufe-448

| Target | Assay | IC₅₀ / K D | Selectivity | |--------|-------|----------------------|------------| | | AlphaScreen competition | 48 nM | ≥ 30‑fold vs. BRD2/3 | | BRD4 (bromodomain‑2) | SPR | 62 nM | 20‑fold vs. BRD2/3 | | CREBBP/EP300 bromodomain | FP assay | >10 µM (inactive) | — | | Off‑target kinases (e.g., CDK9, AURKA) | Kinome scan (KINOMEscan®) | >5 µM | — |

Once you provide these details, I can draft a structured report including an executive summary, detailed analysis, and conclusions. Could you clarify the subject area associated with JUFE-448? JUFE-448