A: Only if you use Boot Camp or a Windows virtual machine. The original ISO is a Windows executable. Mac users should buy the Feral Interactive port.
However, downloading an ISO from a random website walks a legal tightrope. Rome Total War Iso
For players looking to "unlock" all factions (like the Gauls or Macedon) by editing the game's internal text files: A: Only if you use Boot Camp or a Windows virtual machine
(often distributed across 3 discs) typically totals approximately 1.5 GB to 2 GB add an exception. But better yet
A: Cracks often trigger generic "hacktool" warnings. If you trust the source (e.g., GameCopyWorld), add an exception. But better yet, buy the DRM-free GOG version.