The drive mounts as a standard external HDD. You lose proprietary tools (like password locking or backup schedulers), but the drive itself becomes fully functional.
If your Windows 10 PC still won't "see" the drive, try these steps: iomega-storcenter-ix2-200 - LENOVO COMMUNITY Iomega Storage Manager Software Windows 10
To understand why you are having trouble, it is important to understand the history. The Iomega Storage Manager was designed during the era of Windows XP, Vista, and Windows 7. The software relied heavily on specific network discovery protocols (like NetBIOS and specific browser helper objects) that have either been deprecated or significantly tightened in Windows 10. The drive mounts as a standard external HDD