Recent clinical trials (including the COMPARE trial) have used change in Z-score as a primary endpoint to test new drugs. Losartan and irbesartan (ARBs) have been shown to compared to placebo or beta-blockers alone.
In the complex landscape of connective tissue disorders, precision is not just a goal—it is a necessity. For patients living with Marfan syndrome and the physicians who monitor them, the difference between stability and a life-threatening emergency often comes down to millimeters. This is where the concept of the "Marfan Z-score" enters the conversation, serving as the critical mathematical bridge between a patient's anatomy and their clinical risk. marfan z score
That is why the 2010 and 2022 ACC/AHA guidelines for thoracic aortic disease explicitly recommend using Z-scores rather than absolute diameters to guide clinical decisions in Marfan patients. Recent clinical trials (including the COMPARE trial) have