If you are a student or trainee, ask your program director. Many residency programs maintain a shared drive with licensed copies of all essential CLSI documents, including M45.
CLSI Document M45 is available for purchase on the CLSI website. The document is available in PDF format, which can be easily downloaded and accessed on a variety of devices. To access the CLSI Document M45 PDF, follow these steps: clsi document m45 pdf
In microbiology, CLSI M45 addresses a unique problem: most standardized testing works for common bacteria like E. coli or Staph . But what about the "infrequently isolated" pathogens—the Leptospira , the Bartonella , the Abiotrophia ? These organisms require special growth media, prolonged incubation, and customized interpretation. They are not trending in the clinical lab; they are the rare, the fastidious (meaning "hard to please"), and the often overlooked. If you are a student or trainee, ask your program director
| | Old Breakpoint (2015) | New Breakpoint (2022+) | Clinical Impact | |---|---|---|---| | H. influenzae (BLNAR) | Ampicillin ≤2 (S) | Ampicillin ≤1 (S) | False susceptibility if using old PDF | | N. gonorrhoeae | Azithromycin ≤1 (S) | Azithromycin ≤0.25 (S) | Major resistance detection change | | Listeria monocytogenes | No penicillin breakpoint | Penicillin MIC ≤2 (S) | Now aligns with EUCAST | The document is available in PDF format, which