Open Systems Pharmacology

Konten Msbreewc Foursome Wikwik Rame-rame Nih Gokil • Genuine & Instant

Reliable, powerful and easy-to-use modeling & simulation tools for pharmaceutical and other life-sciences applications. Qualified and accepted by the scientific community including academia, regulatory agencies and industry. Available free to everyone.

Essentials

Download OSP Suite

Explore the full functionality of the OSP suite. PBPK, PBPK/PD, QSP – the OSP Suite gives you the flexibility to build it all without having to start from scratch.

Forum

Have your questions answered or provide answers to others. The Forum is a great way to stay up-to-date on the community buzz around OSP.

Documentation

Need to find out how to use a feature? Looking to understand the inner workings of the model? Here you’ll find the extensive OSP manual and qualification documents.

News & Release

Save the Date: OSP Community Conference 2026

In Beerse, Antwerp September 24th and 25th

Open Systems Pharmacology Suite - Version 12 Update 2

We are pleased to announce the new release of the OSP Suite Version 12 Update 2 which is now available for download.

WORKSHOP AT ACOP COLORADO.

Join ESQlabs at the ACoP Conference in Colorado Building Scalable PBPK-QSP Models - Modularization in MoBi for OSP Suite V12.

Ready to take the plunge? Download

ChatGPT‑4 (OpenAI) – Independent Researcher

Indonesia, home to over 270 million net‑users (APJII, 2025), presents a fertile ground for the emergence of localized internet subcultures. While global memes such as “Distracted Boyfriend” or “Woman Yelling at a Cat” have penetrated the Indonesian digital sphere, home‑grown memes often acquire a distinct flavor through the interweaving of regional dialects (e.g., Javanese, Sundanese, Betawi) and culturally resonant symbols (e.g., kucing , sate , gotong‑royong ).

We employ diffusion of innovations (Rogers, 2003) and complex contagion (Centola, 2010) frameworks to model cross‑platform propagation. In particular, we examine multiplex networks where a single user may simultaneously belong to multiple platform layers (e.g., YouTube‑TikTok‑Instagram).

Understanding the lifecycle of locally generated memes provides insight into how digital communities construct meaning, negotiate identity, and mobilise collective action. The “Msbreewc–Wikwik” case offers a rare, well‑documented instance where a narrative meme (the “Foursome”) and a participatory tag (the “Rame‑Rama”) co‑evolve, highlighting the importance of meta‑participation in contemporary internet culture.

The video’s narrative—a mock‑heroic quest to find the “ultimate snack” in a mall—combined slapstick comedy with exaggerated Javanese slang. Within 48 hours, the clip reached 3.2 M views, prompting a wave of duet responses on TikTok.

Publications & Models

Models

Glucose Insulin Model

Scientifically exciting for diabetes researchers. Technically exciting for everyone with PBPK models of glucose, insulin, and glucagon coupled through non-mechanistic PD as well as systems pharmacology PD models.

Publications

Journal Publications

Growing list of scientific journal publications that relates to OSP or describes work with PK-Sim® or MoBi®. Add your own contributions and label them or others appropriately to further grow and structure this database.

Take a look at all our models Browse

Konten Msbreewc Foursome Wikwik Rame-rame Nih Gokil • Genuine & Instant

ChatGPT‑4 (OpenAI) – Independent Researcher

Indonesia, home to over 270 million net‑users (APJII, 2025), presents a fertile ground for the emergence of localized internet subcultures. While global memes such as “Distracted Boyfriend” or “Woman Yelling at a Cat” have penetrated the Indonesian digital sphere, home‑grown memes often acquire a distinct flavor through the interweaving of regional dialects (e.g., Javanese, Sundanese, Betawi) and culturally resonant symbols (e.g., kucing , sate , gotong‑royong ). Konten Msbreewc Foursome Wikwik Rame-rame Nih Gokil

We employ diffusion of innovations (Rogers, 2003) and complex contagion (Centola, 2010) frameworks to model cross‑platform propagation. In particular, we examine multiplex networks where a single user may simultaneously belong to multiple platform layers (e.g., YouTube‑TikTok‑Instagram). In particular, we examine multiplex networks where a

Understanding the lifecycle of locally generated memes provides insight into how digital communities construct meaning, negotiate identity, and mobilise collective action. The “Msbreewc–Wikwik” case offers a rare, well‑documented instance where a narrative meme (the “Foursome”) and a participatory tag (the “Rame‑Rama”) co‑evolve, highlighting the importance of meta‑participation in contemporary internet culture. The video’s narrative—a mock‑heroic quest to find the

The video’s narrative—a mock‑heroic quest to find the “ultimate snack” in a mall—combined slapstick comedy with exaggerated Javanese slang. Within 48 hours, the clip reached 3.2 M views, prompting a wave of duet responses on TikTok.

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